2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-150012S2
    N-Lactoyl-phenylalanine-d5 3080778-97-5 98%
    N-Lactoyl-phenylalanine-d5 (Lac-Phe-d5) is the deuterium labeled N-Lactoyl-phenylalanine (HY-150012). N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance.
    N-Lactoyl-phenylalanine-d5
  • HY-A0132S14
    N-Acetyl-D-glucosamine-d3 77369-11-0 98%
    N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.
    N-Acetyl-D-glucosamine-d3
  • HY-B0389S13
    D-Glucose-2-13C 105931-74-6 99.74%
    D-Glucose-2-13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response.
    D-Glucose-2-13C
  • HY-N0229S19
    L-Alanine-1,2-13C2-1 920314-10-9 98%
    L-Alanine-1,2-13C2 (Alanine-13C2) is 13C labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1,2-13C2-1
  • HY-N0830S22
    Palmitic acid-13C-1 158045-29-5 98%
    Palmitic acid-13C-1 is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.
    Palmitic acid-13C-1
  • HY-N2024AS2
    Maltose monohydrate-13C 98%
    Maltose monohydrate-13C is the 13C labeled isotope of Maltose monohydrate. Maltose monohydrate is a disaccharide composed of two glucose molecules linked together. Maltose monohydrate is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose monohydrate is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose monohydrate can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders.
    Maltose monohydrate-13C
  • HY-W001117R
    3,5-Dimethoxyphenol (Standard) 500-99-2
    3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves.
    3,5-Dimethoxyphenol (Standard)
  • HY-W001288S
    Indole-4-carboxaldehyde-13C
    Indole-4-carboxaldehyde-13C is the 13C-labeled Indole-4-carboxaldehyde (HY-W001288). Indole-4-carboxaldehyde is an ergot alkaloid precursor. Indole-4-carboxaldehyde attenuates the methylglyoxal (MGO)-induced expression of inflammatory-related genes, such asTNF-α and IFN-γ by activating NF-κB without toxicity in HepG2 cells. Indole-4-carboxaldehyde reduces the MGO-induced AGE formation and the expression of the receptor for AGE (RAGE). Indole-4-carboxaldehyde can be used for the study of hepatic steatosis.
    Indole-4-carboxaldehyde-13C
  • HY-W001542R
    5-Hydroxyoxindole (Standard) 3416-18-0 98%
    5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders.
    5-Hydroxyoxindole (Standard)
  • HY-W001909R
    Myosmine (Standard) 532-12-7 98%
    Myosmine (Standard) is the analytical standard of Myosmine. This product is intended for research and analytical applications. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.
    Myosmine (Standard)
  • HY-W001958R
    Monomethyl octanoate (Standard) 3946-32-5 98%
    Monomethyl octanoate (Standard) (Suberic acid monomethyl ester (Standard)) is the analytical standard of Monomethyl octanoate (HY-W001958). This product is intended for research and analytical applications. Monomethyl octanoate (Suberic acid monomethyl ester) is an ester product. Monomethyl octanoate is a PROTAC linker that can be used in the synthesis of PROTACs, DDD2 (HY-176261).
    Monomethyl octanoate (Standard)
  • HY-W002116R
    Methyl syringate (Standard) 884-35-5 98%
    Methyl syringate is a selective TRPA1 agonist. Methyl syringate regulates food intake and gastric emptying through a TRPA1-mediated pathway. Methyl syringate is an efficient phenolic mediator for bacterial and fungal laccases. Methyl syringate is a chemical marker of Asphodel monofloral honey. Methyl syringate contributes to the antibacterial activity of honey. Methyl syringate inhibits aflatoxin production. Methyl syringate can contribute to weight suppression. Methyl syringate can be studies for cancer prevention (e.g. lung cancer), suppression of hypoxia-induced inflammatory response and tumorigenesis.
    Methyl syringate (Standard)
  • HY-W004078R
    4-Hydroxybenzylamine (Standard) 696-60-6
    4-Hydroxybenzylamine (Standard) is the analytical reference standard of 4-Hydroxybenzylamine (HY-W004078). This product is used for research and analytical applications. 4-Hydroxybenzylamine is a natural biogenic amine. 4-Hydroxybenzylamine can be produced through the breakdown metabolism of glucosinolates, with glutamine serving as the non-classical ammonia donor. 4-Hydroxybenzylamine can be used for studying the biosynthesis of plant amines.
    4-Hydroxybenzylamine (Standard)
  • HY-W004260A
    Arachidic acid sodium 13257-34-6 98%
    Arachidate (sodium) is an ester product.
    Arachidic acid sodium
  • HY-W004263R
    1-Eicosanol (Standard) 629-96-9 98%
    1-Eicosanol (Standard) (Arachidyl alcohol (Standard)) is the analytical standard of 1-Eicosanol (HY-W004263). This product is intended for research and analytical applications. 1-Eicosanol is a natural compound with antioxidant activity found in Justicia insularis leaves. 1-Eicosanol can be used as an antioxidant.
    1-Eicosanol (Standard)
  • HY-W004291S
    Methyl arachidate-d39 39756-40-6 98%
    Methyl arachidate-d39 is the deuterated Methyl arachidate. Methyl arachidate, a natural compound, is a?leukotriene A4 hydrolase?(LTA4H)?inhibitor
    Methyl arachidate-d39
  • HY-W004305S
    Hexadecanal-d5 2703602-66-6 98%
    Hexadecanal-d5 (Palmitaldehyde-d5) is deuterium labeled Hexadecanal. Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression
    Hexadecanal-d5
  • HY-W004661R
    1,4-Dioxane-2,5-diol (Standard) 23147-58-2 98%
    1,4-Dioxane-2,5-diol (Standard) (Hydroxy Acetaldehyde (Standard)) is the analytical standard of 1,4-Dioxane-2,5-diol (HY-W004661). This product is intended for research and analytical applications. 1,4-Dioxane-2,5-diol is an endogenous metabolite.
    1,4-Dioxane-2,5-diol (Standard)
  • HY-W004874R
    2,6-Dimethylhydroquinone (Standard) 654-42-2 98%
    2,6-Dimethylhydroquinone (Standard) is an analytical standard for 2,6-Dimethylhydroquinone (HY-W004874). This product is intended for research and analytical applications. 2,6-Dimethylhydroquinone is a key metabolic intermediate in the degradation of 2,6-xylenol by Mycobacterium strain DM1. 2,6-Dimethylhydroquinone can be used as an early indicator of failure in biological treatment systems.
    2,6-Dimethylhydroquinone (Standard)
  • HY-W005028R
    1-Methylguanidine monohydrochloride (Standard) 21770-81-0 98%
    1-Methylguanidine (monohydrochloride) (Standard) is the analytical standard of 1-Methylguanidine (monohydrochloride) (HY-W005028). This product is intended for research and analytical applications. 1-Methylguanidine hydrochloride is an endogenous metabolite.
    1-Methylguanidine monohydrochloride (Standard)
Cat. No. Product Name / Synonyms Application Reactivity